Parvovirus infection is a common and highly contagious childhood ailment — sometimes called slapped-cheek disease because of the distinctive face rash that develops. Some severe cases, however, have been tied to chronic arthritis and even to the development of rheumatoid arthritis. Parvovirus B19 DNA has been detected in studies in the synovial tissue of patients with rheumatoid arthritis, but other studies have varied in their findings. Arthropathy due … Self Care Fifth disease is usually mild and will go away on its own. In healthy individuals, parvovirus B19 infection has a very low mortality rate. 2016 Oct 21;22(39):8684-8697. doi: 10.3748/wjg.v22.i39.8684. She was noted to have chronic parvovirus infection with persistently detectable viral titers and a novel mutation in the ELANE gene. In patients with chronic hemolytic anemias (and occasionally in immunocompetent hosts) parvovirus B19 infection can cause a transient aplastic crisis. The polyarthritis can be chronic or recurrent, lasting from months to years, resembling rheumatoid arthritis. Human parvovirus, or parvovirus B19, is a common infectious viral disease that is spread from person to person. 1 Joint symptoms usually resolve within two weeks; however, 0–17% of patients has chronic arthritis, 2 generally a symmetric polyarthritis that can resemble rheumatoid arthritis. Current Trends Risks Associated with Human Parvovirus B19 Infection . DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain. Mehraein Y, Lennerz C, Ehlhardt S, Venzke T, Ojak A, Remberger K, Zang KD. In some cases, however, infection is associated with sufficiently severe complications that treatment is indicated and may be lifesaving. This article focuses on the evidence supporting the arthritogenic potential of the B19 virus and the proposed mechanisms that underlie it. OBJECTIVE: We describe a 38-year-old woman who presented with a history of inflammatory arthritis, rash, and daily fevers. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a neuro-immune disease of uncertain pathogenesis. 2003 Aug;16(8):811-7. doi: 10.1097/01.MP.0000083145.68333.9B.  |  Lennerz C, Madry H, Ehlhardt S, Venzke T, Zang KD, Mehraein Y. Clin Rheumatol. Guido M, Tumolo MR, Verri T, Romano A, Serio F, De Giorgi M, De Donno A, Bagordo F, Zizza A. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Detection of parvovirus B19 capsid proteins in lymphocytic cells in synovial tissue of autoimmune chronic arthritis. No Definite Association between Human Parvovirus B19 Infection and Behçet Disease. NIH Parvovirus B19 is a virus that causes several illnesses, including fifth disease — a common childhood ailment known for causing a red rash on the face. Saal JG, Steidle M, Einsele H, Müller CA, Fritz P, Zacher J. Persistence of B19 parvovirus in synovial membranes of patients with rheumatoid arthritis. However, children and men who are infected with parvovirus do not usually suffer from such arthralgia. This site needs JavaScript to work properly. Parvovirus affects people of … Vadivel K, Mageshbabu R, Sankar S, Jain A, Perumal V, Srikanth P, Ranjan GA, Nair A, Simoes EAF, Nandagopal B, Sridharan G. Indian J Med Res. 2017 Sep;146(3):381-385. doi: 10.4103/ijmr.IJMR_225_16. The following symptoms are characteristic: A usual brief viral prodrome with fever, headache, nausea, diarrhea. 1988 Dec;148(12):2587-9. The B19 virus is the only virus in the parvoviridae family that infects humans (Strauss 271). Human parvovirus B19 infection has been shown to occur just prior to development of the onset of CFS/ME in several cases, although B19 seroprevalence studies do not show any significant differences between CFS/ME and controls. Human parvovirus B19 infections are common. While in patients who are immunocompromised persistent B19 infection is likely to … Biochemistry. The rheumatoid factor blood test is usually negative, but can be positive. World J Gastroenterol. In most patients, polyarthritis resolves after 2–3 weeks but chronic arthritis has been described with parvovirus B19. They typically do not get a rash of the face, but can have the lacey rash of the body. NLM [Research on Parvovirus B19 infections and chronic articular manifestations in a Tunisian hospital]. HHS Parvovirus B19 infection can cause painful or swollen joints (polyarthropathy syndrome), which is more common in adults. In adults, the most prominent symptom of parvovirus infection is joint soreness, typically in the hands, wrists, knees and ankles. This can lead to severe anemia and other complications, but these are not very common. (2) This report* was developed to assist physicians, public health officials, and other health-care professionals respond to public concerns about recently recognized, serious complications of human parvovirus B19 (B19) infection, including transient aplastic crisis (TAC), chronic anemia, and fetal death.  |  Clinical management of an adult with erythema infectiosum: a retrospective case report. This virus is responsible for flu-like symptoms (fever, malaise, and myalgia) as well as fifth disease, which leads to an erythematous rash on the face known as ?slapped check.? Transient rheumatoid factor positivity in acute human parvovirus B19 infection. Chronic … Sanchez JL, Romero Z, Quinones A, Torgeson KR, Horton NC. Parvovirus B19 displays tropism in response to erythroid progenitor cells that cause the transient aplastic crisis in individuals who have an underlying hemolytic disorder. NLM Epub 2016 Nov 17. 2019 Mar;8(3):1257-1259. doi: 10.4103/jfmpc.jfmpc_25_19. Vadivel K, Ramamurthy M, Sankar S, Jain A, Srikanth P, Ghosh AR, Nandagopal B, Nair A, Sridharan G. Indian J Med Res. 1993 May;19(2):457-75. [Various clinical symptoms in human parvovirus B19 infection]. Parvovirus B19 DNA has been detected in studies in the synovial tissue of patients with rheumatoid arthritis, but other studies have varied in their findings. However, parvovirus B19 infections can result in serious complications for people with weakened immune systems or chronic anemia. Treatment of arthritis associated with parvovirus B19 infection is symptomatic, consisting primarily of administration of analgesics and NSAIDs. 2000 Jul;12(4):289-94. doi: 10.1097/00002281-200007000-00010. (1) In immunocompromised patients’ persistence of parvovirus B19 may cause pure red cell aplasia and chronic anemia. 2000 Feb 10;120(4):455-8. Its name, ?B19,? Local outbreaks of human parvovirus infection tend to be cyclical. 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